Ferencvaros or Djurgarden await the winners of the one-off tie in Glasgow.
Neil Lennon says he has already picked his team to face KR and though new signing Albian Ajeti will be in the squad the striker will not start the match
Fellow forwards Leigh Griffiths and Mikey Johnston are missing for the hosts, who last played on 9 August.
Their scheduled Scottish Premiership matches against St Mirren and Aberdeen were called off after defender Boli Bolingoli flew to Spain, failed to quarantine, then played as a substitute in the 1-1 draw with Kilmarnock at Rugby Park.
The Icelandic league was suspended because of Covid-19 cases at the time of the draw but resumed at the weekend, with KR suffering a 2-1 home defeat by Hafnarfjordur.
Celtic manager Neil Lennon: "Preparation has been good even though we missed out on a couple of games. One-legged ties is the new norm. I'd much prefer the two-legged affairs but we know what we have to do. The Champions League is one of our priorities for the season."
KR Reykjavik manager Runar Kristinsson: "We know we are going to sit back and defend a lot and hopefully we can get some positive things from our defending at the beginning that gives us belief in what we are doing. It's not going to be so hectic to play with no supporters, so I think it will help us a little bit."
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